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Articles and Publications

(present - 1988)

The interactions of multisensory integration with endogenous and exogenous attention.
Tang X, Wu J, Shen Y. Neurosci Biobehav Rev. 2016 Feb;61:208-24. doi: 10.1016/j.neubiorev.2015.11.002. Epub 2015 Nov 10. Review.

Deep Anterior Lamellar Keratoplasty Versus Penetrating Keratoplasty: A Meta-Analysis of Randomized Controlled Trials. Chen G, Tzekov R, Li W, Jiang F, Mao S, Tong Y. Cornea. 2016 Feb;35(2):169-74. doi: 10.1097/ICO.0000000000000691.

A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure. Zakirova Z, Crynen G, Hassan S, Abdullah L, Horne L, Mathura V, Crawford F, Ait-Ghezala G. Front Integr Neurosci. 2016 Jan 12;9:71. doi: 10.3389/fnint.2015.00071. eCollection 2015.

Plasma lipidomic profiling in a military population of mTBI and PTSD with APOE ε4 dependent effect. Emmerich T, Abdullah L, Crynen G, Dretsch M, Evans J, Ait-Ghenzala G, Reed J, Montague H, Chaytow H, Mathura V, Martin J, Pelot R, Ferguson S, Bishop A, Phillips J, Mullan M, Crawford FC. J Neurotrauma. 2015 Dec 30

HIV-1 protease substrate-groove: Role in substrate recognition and inhibitor resistance. Laco GS. Biochimie. 2015 Nov;118:90-103. doi: 10.1016/j.biochi.2015.08.009. Epub 2015 Aug 20.

Air Pollution Exposure and Physical Activity in China: Current Knowledge, Public Health Implications, and Future Research Needs. Lü J, Liang L, Feng Y, Li R, Liu Y. Int J Environ Res Public Health. 2015 Nov 20;12(11):14887-97. doi: 10.3390/ijerph121114887. Review.

Ultrastructural Changes in the White and Gray Matter of Mice at Chronic Time Points After Repeated Concussive Head Injury. Ojo JO, Bachmeier C, Mouzon BC, Tzekov R, Mullan M, Davies H, Stewart MG, Crawford F. J Neuropathol Exp Neurol. 2015 Oct;74(10):1012-35. doi:10.1097/NEN.0000000000000247.

Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment. White RF, Steele L, O'Callaghan JP, Sullivan K, Binns JH, Golomb BA, Bloom FE, Bunker JA, Crawford F, Graves JC, Hardie A, Klimas N, Knox M, Meggs WJ, Melling J, Philbert MA, Grashow R. Cortex. 2015 Sep 25. pii: S0010-9452(15)00332-9. doi: 10.1016/j.cortex.2015.08.022.

Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis. Chen G, Tzekov R, Li W, Jiang F, Mao S, Tong Y. Sci Rep. 2015 Sep 28;5:14517. doi: 10.1038/srep14517.

Sex differences in drug addiction and response to exercise intervention: From human to animal studies. Zhou Y, Zhao M, Zhou C, Li R. Front Neuroendocrinol. 2015 Jul 13. pii: S0091-3022(15)30001-7. doi: 10.1016/j.yfrne.2015.07.001.

iTRAQ-Based Proteomic Analysis of Visual Cycle-Associated Proteins in RPE of rd12 Mice before and after RPE65 Gene Delivery. Zheng Q, Ren Y, Tzekov R, Hua S, Li M, Pang J, Qu J, Li W. J Ophthalmol. 2015;2015:918473.

Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis. Li J, Zhao Y, Li R, Broster LS, Zhou C, Yang S. PLoS One. 2015 Jun 29;10(6):e0131820.

Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men. Ojo JO, Mouzon BC, Crawford F. Exp Neurol. 2015 Jun 6. pii: S0014-4886(15)30015-7.

Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.  Verma M, Beaulieu-Abdelahad D, Ait-Ghezala G, Li R, Crawford F, Mullan M, Paris D. PLoS One. 2015 May 26;10(5):e0128224.

Impact of age-related neuroglial cell responses on hippocampal deterioration. Ojo JO, Rezaie P, Gabbott PL, Stewart MG. Front Aging Neurosci. 2015 Apr 29;7:57.

Mini review: linkage between α-Synuclein protein and cognition. Saleh H, Saleh A, Yao H, Cui J, Shen Y, Li R. Transl Neurodegener. 2015 Mar 28;4:5.

Gulf war agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of gulf war illness. Zakirova Z, Tweed M, Crynen G, Reed J, Abdullah L, Nissanka N, Mullan M, Mullan MJ, Mathura V, Crawford F, Ait-Ghezala G. PLoS One. 2015 Mar 18;10(3):e0119579. doi: 10.1371/journal.pone.0119579. eCollection 2015.

Bevacizumab versus ranibizumab for neovascular age-related macular degeneration: a meta-analysis of randomized controlled trials. Chen G, Li W, Tzekov R, Jiang F, Mao S, Tong Y. Retina. 2015 Feb;35(2):187-93. doi: 10.1097/IAE.0000000000000301.

Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema: a meta-analysis of randomized controlled trials. Chen G, Li W, Tzekov R, Jiang F, Mao S, Tong Y. PLoS One. 2014 Dec 26;9(12):e115797. doi: 10.1371/journal.pone.0115797. eCollection 2014.

ISCEV Standard for full-field clinical electroretinography (2015 update). McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M. Doc Ophthalmol. 2015 Feb;130(1):1-12. doi: 10.1007/s10633-014-9473-7. Epub 2014 Dec 14.

The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-ß production and Tau hyperphosphorylation. Paris D, Ait-Ghezala G, Bachmeier C, Laco G, Beaulieu-Abdelahad D, Lin Y, Jin C, Crawford F, Mullan M. J Biol Chem. 2014 Dec 5;289(49):33927-44. doi: 10.1074/jbc.M114.608091. Epub 2014 Oct 20.  full article link

Impact of physical exercise on substance use disorders: a meta-analysis. Wang D, Wang Y, Wang Y, Li R, Zhou C. PLoS One. 2014 Oct 16;9(10):e110728. doi: 10.1371/journal.pone.0110728. eCollection 2014.

Why women see differently from the way men see? A review of sex differences in cognition and sports. Li R. J Sport Health Sci. 2014 Sep;3(3):155-162. PubMed PMID: 25520851; PubMed Central PMCID: PMC4266559.

Deficiency of GDNF Receptor GFRα1 in Alzheimer's Neurons Results in Neuronal Death. Konishi Y, Yang LB, He P, Lindholm K, Lu B, Li R, Shen Y. J Neurosci. 2014 Sep 24;34(39):13127-38. doi: 10.1523/JNEUROSCI.2582-13.2014.

Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury. Abdullah L, Evans JE, Ferguson S, Mouzon B, Montague H, Reed J, Crynen G, Emmerich T, Crocker M, Pelot R, Mullan M, Crawford F. FASEB J. 2014 Dec;28(12):5311-21. doi: 10.1096/fj.14-258228. Epub 2014 Sep 10.

Deficiency of Patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice. He P, Staufenbiel M, Li R, Shen Y. Hum Mol Genet. 2014 Dec 15;23(24):6512-27. doi: 10.1093/hmg/ddu370. Epub 2014 Jul 15.

Apolipoprotein E Isoform-Specific Effects on Lipoprotein Receptor Processing. Bachmeier C, Shackleton B, Ojo J, Paris D, Mullan M, Crawford F.  Neuromolecular Med. 2014 Jul 12.

Targeting TNF: a therapeutic strategy for Alzheimer's disease. Cheng X, Shen Y, Li R. Drug Discov Today. 2014 Nov;19(11):1822-7. doi: 10.1016/j.drudis.2014.06.029. Epub 2014 Jul 4.

Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury. Ojo JO, Greenberg MB, Leary P, Mouzon B, Bachmeier C, Mullan M, Diamond DM, Crawford F. Front Behav Neurosci. 2014 Jun 23;8:213. doi:10.3389/fnbeh.2014.00213. eCollection 2014.

Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure. Ojo JO, Abdullah L, Evans J, Reed JM, Montague H, Mullan MJ, Crawford FC. Neuropathology. 2014 Apr;34(2):109-27. doi: 10.1111/neup.12061. Epub 2013 Sep 30.

Anatabine Attenuates Tau Phosphorylation and Oligomerization in P301S Tau Transgenic Mice. Paris D, Beaulieu-Abdelahad D, Ait-Ghezala G, Mathura V, Verma M, et al, (2014) Brain Disord Ther 3:126. doi: 10.4172/2168-975X.1000126

Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα. Jiang H, He P, Xie J, Staufenbiel M, Li R, Shen Y. (2014) Hum Mol Genet. 2014 Sep 15;23(18):4906-18. doi: 10.1093/hmg/ddu206. Epub 2014 May 13.

Occludin Deficiency with BACE1 Elevation in Cerebral Amyloid Angiopathy. Cheng X, He P, Yao H, Dong Q, Li R, Shen Y. Neurology. 2014 May 13;82(19):1707-15

Brain Sex Matters: estrogen in cognition and Alzheimer's disease. Molecular and Cellular Endocrinology. Li R, Cui J, Shen Y. Mol Cell Endocrinol 2014 May 25;389(1-2):13-21.

Repetitive mild traumatic brain injury causes optic nerve and retinal damage in a mouse model. Tzekov R, Quezada A, Gautier M, Biggins D, Frances C, Mouzon B, Jamison J, Mullan M, Crawford F.  J Neuropathol Exp Neurol. 2014 Apr;73(4):345-61.

Increased Plasma TACE Activity in Subjects with Mild Cognitive Impairment and Patients with Alzheimer's Disease. Sun Q, Hampel H, Blennow K, Lista S, Levey A, Tang B, Li R, Shen Y. J Alzheimers Dis. 2014 Mar;41(3):877-86. doi: 10.3233/JAD-140177.

Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model. Mouzon BC, Bachmeier C, Ferro A, Ojo JO, Crynen G, Acker CM, Davies P, Mullan M, Stewart W, Crawford F. Ann Neurol. 2014 Feb;75(2):241-54. doi: 10.1002/ana.24064. Epub 2014 Feb 20.

Sex differences in cognitive impairment and Alzheimer's disease. Frontiers in Neuroendocrinology. Li R, Singh M. Front Neuroendocrinol. 2014 Jan 13. pii: S0091-3022(14)00003-X. doi: 10.1016/j.yfrne.2014.01.002.

High activities of BACE1 in brains with mild cognitive impairment. Cheng X, He P, Lee T, Yao H, Li R, Shen Y. American Journal of Pathology.184:1-7

 Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease. Cui J, Jothishankar B, He P, Staufenbiel M, Shen Y, Li R. (2014) Molecular Neurobiology. 49(1)103-112

Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin. Abdullah L, Evans JE, Montague H, Reed JM, Moser A, Crynen G, Gonzalez A, Zakirova Z, Ross I, Mullan C, Mullan M, Ait-Ghezala G, Crawford F.  Neurotoxicol Teratol. 2013 Nov-Dec;40:74-84.

What does complement do in Alzheimer's disease? Old molecules with new insights. Shen Y, Yang LB, Li R. (2013) Translational Neurodegeneration. 2(1):21.

Vision function abnormalities in Alzheimer disease. Tzekov R1, Mullan M. (2013) Surv Ophthalmol. 2013 Oct 22.

Mini review: Linkages between essential tremor and Parkinson's disease? Frontiers in Cellular Neuroscience. Wu Y, Ding J, Gao Y, Chen S, Li L, Li R. (2013) Jul 31;7:118.

An old method facing a new challenge: re-visiting housekeeping protein as internal reference control for neuroscience research. Li R*, Shen Y. (2013) Life Science. 92(13):747-751.

ß-secretase: Its Biology as a Therapeutic Target in Diseases. Wang H, Li R and Shen Y (2013). Trends in Pharmacological Sciences. Feb 26.

Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice. Ojo JO, Mouzon B, Greenberg MB, Bachmeier C, Mullan M, Crawford F. J Neuropathol Exp Neurol. 2013 Feb;72(2):137-51. doi: 10.1097/NEN.0b013e3182814cdf.

Tissue and cell-specific estrogen synthesis and signaling pathways during ageing: from peripheral to brain. Cui J, Shen Y and Li R (2013). Trends in Molecular Medicine. Jan. 21. doi:pii: S1471-4914(12)00244-4.

Elevated Plasma Levels of Soluble TNFRs and TACE Activity in Alzheimer's Disease Patients of Northern Han Chinese Descent. Bai L, Song N, Yu J, Tan L, Shen Y, Xie J, Jiang H. (2013). Current Alzheimer Research 10(1):57-62.

Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson's disease. Yu X, Du T, Song N, He Q, Shen Y, Jiang H, and Xie J (2013). Neurology, Jan. 29; 80(5): 492-495.

Long-term treatment of thalidomide ameliorates Alzheimer-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease. He P, Cheng X, Staufenbiel M, Li R and Shen Y (2013). PLoS One, Feb.6, 8(2): e55091.

Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces abnormal processing of amyloid precursor protein in a mouse model of Alzheimer's Disease. He P, Li P, Hua Q, Liu Y, Staufenbiel M, Li R, and Shen Y (2013). PLoS One, March 5. 8(3): e58181.

Amelioration of experimental autoimmune encephalomyelitis by anatabine. Paris D, Beaulieu-Abdelahad D, Mullan M, Ait-Ghezala G, Mathura V, Bachmeier C, Crawford F, Mullan MJ. PLoS One. 2013;8(1):e55392. doi: 10.1371/journal.pone.0055392. Epub 2013 Jan 30.

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation. Paris D, Beaulieu-Abdelahad D, Abdullah L, Bachmeier C, Ait-Ghezala G, Reed J, Verma M, Crawford F, Mullan M. Eur J Pharmacol. 2013 Jan 5;698(1-3):145-53. doi: 10.1016/j.ejphar.2012.11.017. Epub 2012 Nov 21.

Early reproductive experiences in females make differences in cognitive function later in life. Li R, Cui J, Jothishankar B, Shen J, He P, Shen Y. Journal of Alzheimer's Disease.  J Alzheimers Dis. 2013;34(3):589-94. doi: 10.3233/JAD-122101.

Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer's Transgenic Mice. Li R, He P, Cui J, Staufenbiel M, Harada N, Shen Y.  Mol Neurobiol. 2013 Jun;47(3):857-67. doi: 10.1007/s12035-012-8377-3.

Bid signal pathway components are identified in the temporal cortex with Parkinson disease. Neurology. Jiang H, He P, Adler CH, Shill H, Beach TG, Li R, Shen Y. 2012 79(17):1767-73.

New evidence of mitochondria dysfunction in the female Alzheimer's brain: deficiency of estrogen receptor-?. Long J, He P, Shen Y, Li R. Journal of Alzheimer's Disease. 2012 30:545-58.

Repetitive Mild Traumatic Brain Injury in a Mouse Model Produces Learning and Memory Deficits Accompanied by Histological Changes. Mouzon B, Chaytow H, Crynen G, Bachmeier C, Stewart J, Mullan M, Stewart W, Crawford F. J Neurotrauma. 2012

Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood-Brain Barrier. Bachmeier C, Beaulieu-Abdelahad D, Crawford F, Mullan M, Paris D. J Mol Neurosci. 2013 Feb;49(2):270-6. doi: 10.1007/s12031-012-9866-6. Epub 2012 Aug 14.

Lipidomic Profiling of Phosphocholine Containing Brain Lipids in Mice with Sensorimotor Deficits and Anxiety-Like Features After Exposure to Gulf War Agents. Abdullah L, Evans JE, Bishop A, Reed JM, Crynen G, Phillips J, Pelot R, Mullan MA, Ferro A, Mullan CM, Mullan MJ, Ait-Ghezala G, Crawford FC.  Neuromolecular Med. 2012 Dec;14(4):349-61. doi: 10.1007/s12017-012-8192-z. Epub 2012 Jul 14.

A Multifaceted Role for apoE in the Clearance of Beta-Amyloid across the Blood-Brain Barrier. Bachmeier C, Paris D, Beaulieu-Abdelahad D, Mouzon B, Mullan M, Crawford F.  Neurodegener Dis. 2013;11(1):13-21. Epub 2012 May 8.

Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. He P, Liu Q, Wu J, Shen Y.  FASEB J. 2012 26(1):334-45.

New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-β. Long J, He P, Shen Y, Li R. (2012). Journal of Alzheimer's Disease. 30(3): 545-58.

Depletion of GGA1 and GGA3 mediates post-injury elevation of BACE1. Walker KR, Kang EL, Whalen MJ, Shen Y and Tesco G. (2012). Journal of Neuroscience. 32(30): 10423-37.

Delayed audiovisual integration of patients with mild cognitive impairment and Alzheimer's disease compared with normal aged Controls. Wu J, Yang J, Yu, Y, Li Q, Nakamura N, Shen Y, Ohta Y, Yu, S, and Abe K (2012). Journal of Alzheimer's Disease. 32: 317-328.

Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice. Li R, Cui J, He P, Staufenbiel M, Harada N, Shen Y (2012). Mol Neurobiol. 2013 Jun;47(3):857-67. doi: 10.1007/s12035-012-8377-3. Epub 2012 Nov 20.

Jiang H, He P, Adler CH, Shill H, Beach TG, Li, R, and Shen Y. (2012). Bid signal pathway components are identified in the temporal cortex in brains with Parkinson's disease. Neurology, 79(17):1767-73.

MicroRNA-205 regulates the Expression of Parkinson's disease-related Leucine-rich Repeat Kinase 2 Protein.  Cho HJ, Jin SM, Ding J, Xie C, Yu J, Parisiadou L, Sun L, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans J-M, He P, Troncoso J, Shen Y, Cai H (2013).  Human Molecular Genetics, Feb 1; 22(3):608-20. Epub 2012 Nov 2.

Li R, Cui J, Jothishankar B, Shen J, He P, Shen Y. (2012). Early reproductive experiences in females make differences in cognitive function later in life. Journal of Alzheimer's Disease (JAD). Dec. 27.

Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener. 2011 6:69.

Abdullah L, Crynen G, Reed J, Bishop A, Phillips J, Ferguson S, Mouzon B, Mullan M, Mathura V, Mullan M, Ait-Ghezala G, Crawford F. Proteomic CNS Profile of Delayed Cognitive Impairment in Mice Exposed to Gulf War Agents. Neuromolecular Med. 2011 13(4):275-88

Paris D, Beaulieu-Abdelahad D, Bachmeier C, Reed J, Ait-Ghezala G, Bishop A, Chao J, Mathura V, Crawford F, Mullan M. Anatabine lowers Alzheimer's Abeta production in vitro and in vivo. Eur J Pharmacol. 2011 670(2-3):384-91.

Crawford FC, Crynen G, Reed J, Mouzon B, Bishop A, Katz B, Ferguson S, Phillips J, Ganapathi V, Mathura V, Roses A, Mullan M. Identification of plasma biomarkers of TBI outcome using proteomic approaches in an APOE mouse model. J Neurotrauma. 2011 29(2):246-60

Luis CA, Abdullah L, Ait-Ghezala G, Mouzon B, Keegan AP, Crawford F, Mullan M. Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum Beta-Amyloid. Int J Alzheimers Dis. 2011 2011:786264.

Paris D, Mathura V, Ait-Ghezala G, Beaulieu-Abdelahad D, Patel N, Bachmeier C, Mullan M. Flavonoids lower Alzheimer's Abeta production via an NFkB dependent mechanism. Bioinformation. 2011 6(6):229-36.

Bachmeier CJ, Beaulieu-Abdelahad D, Mullan MJ, Paris D. Selective dihydropyiridine compounds facilitate the clearance of beta-amyloid across the blood-brain barrier. Eur J Pharmacol. 2011 659(2-3):124-9.

Bachmeier CJ, Beaulieu-Abdelahad D, Mullan MJ, Paris D. Epitope-dependent effects of beta-amyloid antibodies on beta-amyloid clearance in an in vitro model of the blood-brain barrier. Microcirculation. 2011 18(5):373-9

Bachmeier CJ, Beaulieu-Abdelahad D, Ganey NJ, Mullan MJ, Levin GM. Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos. 2011 32:233-44.

Bakshi P, Margenthaler E, Reed J, Crawford F, Mullan M. Depletion of CXCR2 inhibits gamma-secretase activity and amyloid-beta production in a murine model of Alzheimer's disease. Cytokine. 2011 53:163-169.

Paris D, Bachmeier C, Patel N, Quadros A, Volmar CH, Laporte V, Ganey J, Beaulieu-Abdelahad D, Ait-Ghezala G, Crawford F, Mullan MJ. Selective antihypertensive dihydropyridines lower Abeta accumulation by targeting both the production and the clearance of Abeta across the blood-brain barrier. Mol Med. 2011 17:149-62

Yang J, Han H, Chui D, Shen Y and Wu J (2011). Prominent activation of the intraparietal and somatosensory areas during angle discrimination by intra-active touch. Human Brain Mapping, 33:2957-2970.

Ewers M, Cheng X, Nural HF, Walsh C, Meindl T, Teipel SJ, Buerger K, Shen Y, Hampel H. (2010). IncreasedCSF- BACE1 activity predicts hippocampus atrophy in Alzheimer's disease. Journal of Alzheimer's Disease, 25(2):373-81.

He P, Liu Q, Wu J and Shen Y (2011). Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. FASEB Journal. 26(1): 334-45.

Jiang H, Hampel H, Prvulovic D, Wallins A, Blennow K, Li R, and Shen Y (2011). Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Molecular Neurodegeneration. Oct. 6; 61(1):69.

Bachmeier C, Mullan M, Paris D. Characterization and use of human brain microvascular endothelial cells to examine beta-amyloid exchange in the blood-brain barrier. Cytotechnology. 2010 62:519-29.

Mathura VS, Patel N, Corbin Bachmeier C, Mullan M, Paris D. A 3D-QSAR model based screen for dihydropyridine-like compound library to identify inhibitors of amyloid beta production. Bioinformation 5:122-127.

Kennelly SP, Abdullah L, Paris D, Parish J, Mathura V, Mullan M, Crawford F, Lawlor BA, Kenny RA. Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study. Int J Geriatr Psychiatry. 2010 26(10):1038-45

Paris D, Patel N, Ganey GJ, Laporte V, Quadros A, Mullan MJ. Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease. J Neurosci. 2010 30:11251-11258.

Cheng X, Yang L, He P, Li R, Shen Y. (2010). Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. Journal of Alzheimer's Disease. 19(2):621-30.

Paris D, Patel N, Ganey GJ, Laporte V, Quadros A, Mullan MJ. Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer's Abeta Peptide. Int J Pept Res and Therap. 2010 16:23-30

Paris D, Ganey GJ, Laporte V, Patel N, Beaulieu-Abdlahad D, Bachmeier C, March A, Ait-Ghezala G, Mullan MJ. Reduction of beta amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2010 7:17

Ferguson S, Mouzon B, Kayihan G, Wood M, Poon F, Doore S, Mathura V, Humphrey J, O'Steen B, Hayes R, Roses A, Mullan M, Crawford F. APOE genotype and oxidative stress response to Traumatic Brain Injury. Neuroscience. 2010 168:811-819.

Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D. Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. J Neurochem. 2010 112(1):66-76.

Furuya T., Kim M., Lipinski M., Li J., Kim D., Lu T., Shen, Y., Rameh L., Yankner B., Tsai LH and Yuan J. (2010). Negative regulation of Vps34 by Cdk mediated phosphorylation. Cell Molecular Cell. 38(4):500-11.

McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R. (2010). Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. Journal of Neuroscience. 30(21):7326-34.

Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Li Gan L (2010). Acetylation of tau inhibits Its degradation and contributes to tauopathy. Neuron. 67: 953-966.

Sabbagh MN, Nural H, He P, Sirrel S, Belden C, Liebsack C, Li R, Shen Y. (2010). Rationale and strategy for thalidomide as a BACE1 inhibitor for a phase II randomized clinical trial in mild-to-moderate Alzheimer's disease. Alzheimers Dementia 6(4):0

Kayihan GC, Wood M, Mouzon B, Ferguson S, Mullan M and Crawford F. (2009) Gulf War agents trigger discrete transcriptional changes in cultured human neurons. J of Toxicology and Environmental Chem. 2010 92(9) 1783-1799.

Abdullah L, Reed J, Kayihan G, Mathura V, Mouzon B, et al. (2009) Proteomic Analysis of Human Neuronal Cells Treated with the Gulf WarAgent Pyridostigmine Bromide. J Proteomics Bioinform. 2: 439-444.doi:10.4172/jpb.1000103. (10/2009)

Bakshi P, Jin C, Broutin P, Berhane B, Reed J, Mullan M. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta. Bioorg Med Chem 2009 17(23):8102-12.

Abdullah L, Luis C, Paris D, Mouzon B, Ait-Ghezala G, Keegan AP, Wang D, Crawford F, Mullan M. Serum Abeta levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohort. Mol Med. 2009 15(11-12):432-7.

Mathura VS, Paris D, Mullan MJ. A novel physico-chemical property based model for studying the effects of mutation on the aggregation of peptides. Protein Pept Lett. 2009 16(8):991-8.

Crawford F, Wood M, Ferguson S, Mathura V, Gupta P, Humphrey J, Mouzon B, Laporte V, Margenthaler E, O'Steen B, Hayes R, Roses A, Mullan M. Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury. Neuroscience. 2009 159(4):1349-62.

Volmar CH, Ait-Ghezala G, Frieling J, Weeks OI, Mullan MJ. CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling. Exp Cell Res. 2009 315(13):2265-74.

Abdullah L, Luis C, Paris D, Ait-Ghezala G, Mouzon B, Allen E, Parrish J, Mullan MA, Ferguson S, Wood M, Crawford F, Mullan M. High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients. Mol Med. 2009 15(3-4):95-100.

Luis C, Abdullah L, Paris D, Quadros A, Mullan MA, Mouzon B, Ait-ghezala G, Paris D, Crawford F and Mullan M. Serum beta-amyloid correlates with neuropsychological impairment. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2009 Mar;16(2):203-18.

Luis CA, Keegan AP, Mullan M. Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US. Int J Geriatr Psychiatry. 2009 Feb;24(2):197-201.

Bakshi P, Margenthaler E, Laporte V, Crawford F, Mullan M. Novel role of CXCR2 in regulation of gamma-secretase activity. ACS Chem Biol. 2008 Dec 19;3(12):777-89.

Ait-ghezala G, Abdullah L, Volmar CH, Paris D, Luis CA, Quadros A, Mouzon B, Mullan MA, Keegan AP, Parrish J, Crawford FC, Mathura VS, Mullan MJ. Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease. Cytokine. 2008 Nov;44(2):283-7.

Laporte V, Ait-Ghezala G, Volmar CH, Ganey C, Ganey N, Wood M, Mullan M. CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice. Brain Res. 2008 1231:132-42.

Patel N, Quadros A, Brem S, Wotoczek-Obadia M, Mathura V, Laporte V, Mullan M, Paris D. Potent anti-angiogenic motifs within the Alzheimer B-amyloid peptide. Amyloid. 2008 Mar;15(1):5-19.

Poon HF, Abdullah L, Reed J, Doore SM, Laird C, Mathura V, Mullan M, Crawford F. Improving image analysis in 2DGE-based redox proteomics by labeling protein carbonyl with fluoroscent hydroxylamine. Biol Proced Online. 2007 Dec 19;9:65-72. doi: 10.1251/bpo134.

Volmar CH, Ait-Ghezala G, Frieling J, Paris D, Mullan MJ. The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production. Cytokine. 2008 Jun;42(3):336-44. doi: 10.1016/j.cyto.2008.03.007. Epub 2008 Apr 22.

Mathura V, Paris D, Ait-ghezala G, Gupta P, Volmar C, Mullan M. A vector method for comparison of RNA and protein expression levels of cytokines upon CD40L treatment of microglia. IJIB. 2008 Aug;

Mathura V, Rangareddy M, Gupta P, Mullan M. CliniProteus: A flexible clinical trials information management system. Bioinformation. 2007 Dec 28; 2(4): 163-165.

Abdullah L, Paris D, Luis C, Quadros A, Parrish J, Valdes L, Keegan AP, Mathura V, Crawford F, Mullan M. The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels. Neurosci Lett. 2007 Nov 27;428(2-3):53-8. Epub 2007 Oct 2.

Crawford FC, Wood M, Ferguson S, Mathura VS, Faza B, Wilson S, Fan T, O'Steen B, Ait-Ghezala G, Hayes R, Mullan MJ. Genomic analysis of response to traumatic brain injury in a mouse model of Alzheimer's disease (APPsw). Brain Res. 2007 Dec 14;1185:45-58. Epub 2007 Sep 25.

Ait-Ghezala G, Volmar CH, Frieling J, Paris D, Tweed M, Bakshi P, Mullan M. CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway. Eur J Neurosci. 2007 Mar;25(6):1685-95.

Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M. Inhibition of Abeta production by NF-kappaB inhibitors. Neurosci Lett. 2007 Mar 19;415(1):11-6. Epub 2006 Dec 27.

Crowell TA, Luis CA, Cox DE, Mullan M. Neuropsychological comparison of Alzheimer's disease and dementia with lewy bodies. Dement Geriatr Cogn Disord. 2007;23(2):120-5. Epub 2006 Dec 5.

Poon HF, Abdullah L, Mullan MA, Mullan MJ, Crawford FC. Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells. Neurochem Int. 2007 Jan;50(1):69-73. Epub 2006 Sep 7.

Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan MJ. Inhibition of Aβ production by NF-κB inhibitors. Neurosci. Lett. (2006), doi:10.1016/j.neulet.2006.12.029

Crawford FC, Wood ML, Wilson SE, Mathura VS, Geall F, Kolippakkam DN, Mullan MJ. Cocaine induced inflammatory responses in human neuronal progenitor cells.   J Neurochemistry 2006 97:662-674

Laporte V, Ait-Ghezala G, Volmar CH, Mullan M. CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models.   J Neuroinflammation 2006 3:3

Crowell TA, Paramadevan J, Abdullah L, Mullan M. Beneficial effect of cholinesterase inhibitor medications on recognition memory performance in mild to moderate Alzheimer's disease: preliminary findings.  J Geriatr Psychiatry Neurol. 2006 Mar;19(1):13-5.

Abdullah L, Ait-Ghezala G, Crawford F, Crowell TA, Barker WW, Duara R, Mullan M. The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease.  Neurosci Lett. 2006 395:240-243

Borenstein AR, Mortimer JA, Wu Y, Jureidini-Webb FM, Fallin MD, Small BJ, Mullan M, Crawford FC. Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians.  Ethnicity & Disease 2006 16:9-15

Town T, Tan J, Flavell RA, Mullan M. T-cells in Alzheimer's disease.  Neuromolecular Med. 2005;7(3):255-64

Ait-Ghezala G, Mathura VS, Laporte V, Quadros A, Paris D, Patel N, Volmar CH, Kolippakkam D, Crawford F, Mullan M. Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease.  Brain Res Mol Brain Res. 2005 Oct 31;140(1-2):73-85.

Patel NS, Paris D, Mathura V, Quadros AN, Crawford FC, Mullan MJ. Inflammatory cytokine levels correlate with ß-amyloid load in transgenic mouse models of Alzheimer's disease.  J Neuroinflammation. 2005; 2: 9. Published online Mar 11, 2005. doi: 10.1186/1742-2094-2-9

Paris D, Quadros A, Patel N, DelleDonne A, Humphrey J, Mullan M. Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors.  Eur J Pharmacol. 2005 May 2;514(1):1-15.

Paris D, Ait-Ghezala G, Mathura VS, Patel N, Quadros A, Laporte V, Mullan M.  Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells.  Brain Res Mol Brain Res. 2005 May 20;136(1-2):212-30

Mathura VS, Paris D, Ait-Ghezala G, Quadros A, Patel NS, Kolippakkam D, Volmar CH, Mullan MJ. Model of Alzheimer's disease ß-amyloid peptide based on a RNA binding protein.  Biochem Biophys Res Commun. 2005 Jul 1;332(2):585-92

Paris D, Quadros A, Humphrey J, Patel N, Crescentini R, Crawford F, Mullan M.  Nilvadipine antagonizes both A beta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice.  Brain Research 2004 Feb 27;999(1):53-61.

Mott RT, Ait-Ghezala G, Town T, Mori T, Vendrame M, Zeng J, Ehrhart J, Mullan M, Tan J. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production.  Glia. 2004 May;46(4):369-79

Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.  Cancer Res. 2004 May 15;64(10):3586-92

Todd Roach J, Volmar CH, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M. Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice.  Brain Res. 2004 Jul 23;1015(1-2):161-8

Paris D, Patel N, DelleDonne A, Quadros A, Smeed R, Mullan M.  Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis.  Neurosci Lett. 2004 Aug 5;366(1):80-5

Paris D, Townsend K, Quadros A, Humphrey J, Sun J, Brem S, Wotoczek-Obadia M, DelleDonne A, Patel N, Obregon DF, Crescentini R, Abdullah L, Coppola D, Rojiani AM, Crawford F, Sebti SM, Mullan M. Inhibition of angiogenesis by Abeta peptides.  Angiogenesis. 2004;7(1):75-85

Harwood DG, Barker WW, Ownby RL, Mullan M, Duara R.  No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly.  Int J Geriatr Psychiatry. 2004 Dec;19(12):1131-9

Harwood DG, Barker WW, Ownby RL, St George-Hyslop P, Mullan M, Duara R.  Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample.  Int Psychogeriatr. 2004 Sep;16(3):317-26

Paris D, Humphrey J, Quadros A, Patel N, Crescentini R, Crawford F, Mullan M.  Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation.  Neurol Res. 2003 Sep;25(6):642-51.

Crawford FC, Ait-Ghezala G, Morris M, Sutcliffe MJ, Hauser RA, Silver AA, Mullan MJ. Translocation breakpoint in two unrelated Tourette syndrome cases, within a region previously linked to the disorder.  Hum Genet. 2003 Jul;113(2):154-61. Epub 2003 Apr 16.

Quadros A, Patel N, Crescentini R, Crawford F, Paris D, Mullan M.  Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice.  Neurosci Lett. 2003 Dec 15;353(1):66-8.

Townsend KP, Obregon D, Quadros A, Patel N, Volmar Ch, Paris D, Mullan M.  Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature.  Ann N Y Acad Sci. 2002 Nov;977:65-76

Paris D, Townsend KP, Obregon DF, Humphrey J, Mullan M.  Pro-inflammatory effect of freshly solubilized ß-amyloid peptides in the brain.  Prostaglandins Other Lipid Mediat. 2002 Sep;70(1-2):1-12.

Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ.  Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.  Nat Neurosci. 2002 Dec;5(12):1288-93.

Yuspeh RL, Vanderploeg RD, Crowell TA, Mullan M. Differences in executive functioning between Alzheimer's disease and subcortical ischemic vascular dementia.  J Clin Exp Neuropsychol. 2002 Sep;24(6):745-54.

Town T, Vendrame M, Patel A, Poetter D, DelleDonne A, Mori T, Smeed R, Crawford F, Klein T, Tan J, Mullan M. Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's ß-amyloid(1-42).  J Neuroimmunol. 2002 Nov;132(1-2):49-59.

Tan J, Town T, Abdullah L, Wu Y, Placzek A, Small B, Kroeger J, Crawford F, Richards D, Mullan M. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease.  J Neuroimmunol. 2002 Nov;132(1-2):164-72.

Tan J, Town T, Mullan M. CD40-CD40L interaction in Alzheimer's disease.  Curr Opin Pharmacol. 2002 Aug;2(4):445-51.

Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M. p35/Cdk5 pathway mediates soluble ß-amyloid peptid e-induced tau phosphorylation in vitro.  J Neurosci Res. 2002 Aug 1;69(3):362-72

Schinka JA, Town T, Abdullah L, Crawford FC, Ordorica PI, Francis E, Hughes P, Graves AB, Mortimer JA, Mullan M. A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances.  Mol Psychiatry. 2002;7(2):224-8.

Ait-Ghezala G, Abdullah L, Crescentini R, Crawford F, Town T, Singh S, Richards D, Duara R, Mullan M. Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.  Neurosci Lett. 2002 Jun 7;325(2):87-90.

Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. CD40 is expressed and functional on neuronal cells.  EMBO J. 2002 Feb 15;21(4):643-652.

Ait-Ghezala G, Abdullah L, Crescentini R, Crawford F, Town T, Singh S, Richards D, Duara R, Mullan M. Confirmation of association between D10S583 and Alzheimer's disease in a case-control sample. Neurosci Lett. 2002 Jun 7;325(2):87-90.

Paris D, Townsend KP, Humphrey J, Obregon DF, Yokota K, Mullan M.  Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. Atherosclerosis. 2002 Apr;161(2):293-9

Harwood DG, Barker WW, Ownby RL, Mullan M, Duara R.   Apolipoprotein E polymorphism and cognitive impairment in a bi-ethnic community-dwelling elderly sample.  Alzheimer Dis Assoc Disord. 2002 Jan-Mar;16(1):8-14

Schinka JA, Town T, Abdullah L, Crawford FC, Ordorica PI, Francis E, Hughes P, Graves AB, Mortimer JA, Mullan M.  A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Mol Psychiatry. 2002;7(2):224-8.

Russ C, Powell JF, Zhao J, Baker M, Hutton M, Crawford F, Mullan M, Roks G, Cruts M, Lovestone S.  The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis. Neurosci Lett. 2001 Nov 13;314(1-2):92-6

Crawford FC, Vanderploeg RD, Freeman MJ, Singh S, Waisman M, Michaels L, Abdullah L, Warden D, Lipsky R, Salazar A, and Mullan MJ.  APOE genotype influences acquisition and recall following traumatic brain injury.  Neurology. 2002 58(7); 1115-1118

Town T, Tan J, Mullan M.  CD40 signaling and Alzheimer's disease pathogenesis.  Neurochem Int.  2001 Nov-Dec;39(5-6):371-80. Review

Town T, Tan J, Sansone N, Obregon D, Klein T, Mullan M.  Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42.  Neurosci Lett. 2001 Jul 13;307(2):101-4.

Mori T, Paris D, Town T, Rojiani AM, Sparks DL, Delledonne A, Crawford F, Abdullah LI, Humphrey JA, Dickson DW, Mullan MJ.  Cholesterol Accumulates in Senile Plaques of Alzheimer's Disease Patients and in Transgenic APPsw Mice. J Neuropathology and Experimental Neurology. 2001 60(8): 778-85.

Crawford FC, Freeman MJ, Schinka JA, Morris MD, Abdullah LI, Richards D, Sevush S, Duara R, Mullan MJ. Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. Experimental Neurology. 2001 167(2):456-459.

Town T, Schinka J, Tan J, Mullan M. The opioid receptor system and alcoholism: a genetic perspective. Eur J Pharmacol. 2000 Dec 27;410(2-3):243-248. Review.

Crawford F, Abdullah L, Schinka J, Suo Z, Gold M, Duara R, Mullan M. Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease.  Neurosci Lett. 2000 280(3): 215-9.

Suo Z, Su G, Placzek A, Kundtz A, Humphrey J, Crawford F, Mullan M. A beta vasoactivity in vivo. Ann N Y Acad Sci. 2000 Apr;903:156-63.

Crawford F, Freeman M, Abdullah L, Schinka J, Gold M, Duara R, Mullan M. No association between the NOS3 codon 298 polymorphism and Alzheimer's disease in a sample from the United States. Ann Neurol. 2000 May;47(5):687. 

Kuo YM, Crawford F, Mullan M, Kokjohn TA, Emmerling MR, Weller RO, Roher AE. Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease. Mol Med. 2000 May;6(5):430-9.

Small BJ, Graves AB, McEvoy CL, Crawford FC, Mullan M, Mortimer JA. Is APOE--epsilon4 a risk factor for cognitive impairment in normal aging? Neurology. 2000 Jun 13;54(11):2082-8

Sevush S, Peruyera G, Crawford F, Mullan M. Apolipoprotein-E epsilon 4 allele frequency and conferred risk for Cuban Americans with Alzheimer's disease. Am J Geriatr Psychiatry. 2000 Summer;8(3):254-6.

Crawford FC, Freeman MJ, Schinka JA, Abdullah LI, Gold M, Hartman R, Krivian K, Morris MD, Richards D, Duara R, Anand R, Mullan MJ. A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease. Neurology. 2000 Sep 26;55(6):763-8.

Tan J, Town T, Mullan M. CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway. J Biol Chem. 2000 Nov 24;275(47):37224-31.

Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M. CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. J Neurosci. 2000 Oct 15;20(20):7587-94.

Tandon A, Rogaeva E, Mullan M, St George-Hyslop PH. Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins. Curr Opin Neurol. 2000 Aug;13(4):377-84. Review.

Paris D, Town T, Mori T, Parker TA, Humphrey J, Mullan M. Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway. Neurobiol Aging. 2000 Mar-Apr;21(2):183-97.

Paris D, Town T, Humphrey J, Yokota K, Mullan M. Cholesterol modulates vascular reactivity to endothelin-1 by stimulating a pro-inflammatory pathway. Biochem Biophys Res Commun. 2000 Aug 2;274(2):553-8.

Crawford FC, Freeman MJ, Schinka J, Abdullah LI, Richards D, Sevush S, Duara R, Mullan MJ. The genetic association between Cathepsin D and Alzheimer's disease. Neurosci Lett. 2000 Jul 28;289(1):61-5.

Paris D, Town T, Parker T, Humphrey J, Mullan M. beta-Amyloid vasoactivity and proinflammation in microglia can be blocked by cGMP-elevating agents. Ann N Y Acad Sci. 2000 Apr;903:446-50.

Paris D, Town T, Parker T, Humphrey J, Mullan M. A beta vasoactivity: an inflammatory reaction. Ann N Y Acad Sci. 2000 Apr;903:97-109.

Paris D, Town T, Mullan M. Novel strategies for opposing murine microglial activation. Neurosci Lett. 2000 Jan 7;278(1-2):5-8.

Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science. 1999 Dec 17;286(5448):2352-5.

Tan J, Town T, Saxe M, Paris D, Wu Y, Mullan M. Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10. J Immunol. 1999 Dec 15;163(12):6614-21

Tan J, Town T, Suo Z, Wu Y, Song S, Kundtz A, Kroeger J, Humphrey J, Crawford F, Mullan M. Induction of CD40 on human endothelial cells by Alzheimer's beta-amyloid peptides. Brain Res Bull. 1999 Sep 15;50(2):143-8.

King DL, Arendash GW, Crawford F, Sterk T, Menendez J, Mullan MJ. Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease. Behav Brain Res. 1999 Sep;103(2):145-62.

Tan J, Town T, Placzek A, Kundtz A, Yu H, Mullan M. Bcl-X(L) inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells. Neurosci Lett. 1999 Sep 3;272(1):5-8.

Town T, Paris D, Parker TA, Kundtz A, Tan J, Duara R, Gold M, Crawford F, Mullan M. Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E. Am J Med Genet. 1999 Oct 15;88(5):465-8.

Town T, Abdullah L, Crawford F, Schinka J, Ordorica PI, Francis E, Hughes P, Duara R, Mullan M. Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency. Am J Med Genet. 1999 Oct 15;88(5):458-61.

Crawford F, Freeman M, Town T, Fallin D, Gold M, Duara R, Mullan M. No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples. Neurosci Lett. 1999 May 14;266(3):193-6.

Crawford F, Town T, Freeman M, Schinka J, Gold M, Duara R, Mullan M. The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample. Neurosci Lett. 1999 Aug 6;270(3):133-6.

Tan, J, Town T, Paris D, Placzek A, Parker T, Crawford F, Yu H, Humphrey J, Mullan M. Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis. Journal of Neuroimmunology. 1999 Jun 1;97(1-2):77-85.

Arendash GW, Su GC, Crawford FC, Bjugstad KB, Mullan M. Intravascular beta-amyloid infusion increases blood pressure: implications for a vasoactive role of beta-amyloid in the pathogenesis of Alzheimer's disease. Neurosci Lett. 1999 Jun 11;268(1):17-20.

Paris D, Town T, Parker T, Tan J, Humphrey J, Crawford F, & Mullan M. Inhibition of Alzheimers ß-amyloid induced vasoactivity and proinflammatory response in Microglia by cGMP-dependent Mechanism. Experimental Neurology. 1999 157 (1):221-221

Pompl PN, Mullan MJ, Bjugstad K, Arendash GW.  Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease. J Neurosci Methods. 1999 Feb 1;87(1):87-95.

Harwood DG, Barker WW, Loewenstein DA, Ownby RL, St George-Hyslop P, Mullan M, Duara R. A cross-ethnic analysis of risk factors for AD in white Hispanics and white non-Hispanics. Neurology. 1999 Feb;52(3):551-6.

Su GC, Arendash GW, Kalaria RN, Bjugstad KB, Mullan M. Intravascular infusions of soluble beta-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage. Brain Res. 1999 Feb 6;818(1):105-17.

Town T, Paris D, Parker T, Kundtz A, Fallin D, Tan J, Crawford F, Mullan M.  Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E.  Am J Med Genet. 1999 Oct 15;88(5):465-8.

Pompl PN, Mullan M, Bjugstad K, Arendash G. Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease. J Neurosci Methods. 1999 Feb 1;87(1): 87-95.

Su GC, Arendash GW, Kalaria RN, Bjugstad KB, Mullan M. Intravascular infusions of soluble A?compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage. Brain Res. 1999 818 (1): 105-17.

Paris D, Town T, Parker T, Tan J, Humphrey J, Crawford F, Mullan M. Inhibition of Alzheimer's A?induced Vasoactivity and Proinflammatory response in Microglia by cGMP-Dependent Mechanism. Exp. Neurol. 1999 May;157(1): 211-221.

Paris D, Suo Z, Parker T, Town T, Fang C, Humphrey J, Crawford F, Mullan M. Role of Peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's ß-amyloid1-40 peptide. Experimental Neurology 1998 Jul;152(1):116-22.

Suo Z, Humphrey J, Kundtz A, Sethi F, Placzek A, Crawford F, Mullan M. Soluble Alzheimer's ß-amyloid constricts the cerebral vasculature in vivo. Neurosci Lett 1998 257(2): 77-80.

Paris D, Town T, Parker TA, Humphrey J, Mullan M. Isoform-specific vasoconstriction induced by apolipoprotein E and modulation of this effect by Alzheimer's beta-amyloid peptide. Neurosci Lett 1998 256(2): 73-76.

Town T, Paris D, Fallin D, Duara R, Barker W, Crawford F, Mullan M. The -491A/T assocation with Alzheimer's disease: independent risk and linkage disequilibrium with the epsilon alleles. Neurosci Lett 1998 252(2): 95-8.

Crawford F, Fallin D, Suo Z, Abdullah L, Gold M, Gauntlett A, Duara R, Mullan M. The Butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic and community-based populations. Neurosci Lett 1998 249(2-3), 115-118.

Crawford F, Soto C, Suo Z, Fang C, Parker T, Sawar A, Frangione B, Mullan M.  Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate.  FEBS Letters 1998 436(3): 445-8.

Suo Z, Tan J, Placzek A, Crawford F, Fang C, Mullan M. Alzheimer's beta-amyloid Peptides Induce Inflammatory Cascades in Human Vascular Cells: the roles of cytokines and CD40. Brain Research 1998 807 (1-2): 110-117.

Crawford F, Suo ZM, Fang CH, Mullan M  Characteristics of the in vitro vasoactivity of beta-amyloid peptides. Exp Neurol. 1998 Mar;150(1):159-68

Suo Z, Crawford F, Placzek A, Paris D, Fang C, Mullan M. Phenyl-N-Tert-Butyl Nitrone neutralizes the activities of ß-amyloid peptide on both cultured cells and isolated vessels via multiple pathways. heimers Rep 1998 1, 381-387.

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